The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC–
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Perusing redox nanozymes capable of disrupting cellular homeostasis offers new
opportunities to develop cancer-specific therapy, but remains challenging, because most …

Nanozyme catalytic therapy triggered by tumor‐specific endogenous stimuli is an emerging
tumor therapy that attracts wide attention. However, the current therapeutic efficacy of …

Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …

The transformational effect of photoredox catalytic chemistries has inspired new
opportunities, enabling us to interrogate nature in ways that are not possible otherwise and …

How phosphate levels are detected in mammals is unknown. The bone-derived hormone
fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney …