Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies

ROS Soares, DM Losada, MC Jordani, P Évora… - International journal of …, 2019 - mdpi.com
Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

J Wang, S Toan, H Zhou - Angiogenesis, 2020 - Springer
As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

[HTML][HTML] Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway

C Cai, Z Guo, X Chang, Z Li, F Wu, J He, T Cao… - Redox biology, 2022 - Elsevier
Mitophagy preserves microvascular structure and function during myocardial
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …

[HTML][HTML] HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

ZJ Fu, ZY Wang, L Xu, XH Chen, XX Li, WT Liao… - Redox biology, 2020 - Elsevier
In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated
mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury …

[HTML][HTML] Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission

H Zhou, S Wang, P Zhu, S Hu, Y Chen, J Ren - Redox biology, 2018 - Elsevier
Impaired cardiac microvascular function contributes to diabetic cardiovascular complications
although effective therapy remains elusive. Empagliflozin, a sodium-glucose cotransporter 2 …

[HTML][HTML] Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury

J Wang, H Zhou - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways

Y Zhang, Y Wang, J Xu, F Tian, S Hu… - Journal of pineal …, 2019 - Wiley Online Library
Abstract Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to
sustain mitochondrial homeostasis under stress conditions. However, no study has …

[HTML][HTML] DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK …

Q Jin, R Li, N Hu, T Xin, P Zhu, S Hu, S Ma, H Zhu… - Redox biology, 2018 - Elsevier
Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential
axis of mitochondrial quality control that plays a critical role in the development of cardiac …

Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy

H Zhou, P Zhu, J Wang, H Zhu, J Ren… - Cell Death & …, 2018 - nature.com
Disturbed mitochondrial homeostasis contributes to the pathogenesis of cardiac ischemia
reperfusion (IR) injury, although the underlying mechanism remains elusive. Here, we …

[HTML][HTML] Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease

Y Li, J Zhang, J Wan, A Liu, J Sun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …