Mouse models in bone fracture healing research

M Haffner-Luntzer, A Kovtun, AE Rapp… - Current Molecular Biology …, 2016 - Springer
Bone fracture healing is a tightly regulated process involving many cell types, mediators,
and signaling pathways and is still not well understood. During decades, bone healing was …

Biomechanical characteristics of osteoporotic fracture healing in ovariectomized rats: a systematic review

L Chen, L Yang, M Yao, XJ Cui, CC Xue, YJ Wang… - PloS one, 2016 - journals.plos.org
Biomechanical tests are widely used in animal studies on osteoporotic fracture healing.
However, the biomechanical recovery process is still unknown, leading to difficulty in …

The effectiveness of human parathyroid hormone and low-intensity pulsed ultrasound on the fracture healing in osteoporotic bones

KQ Mansjur, S Kuroda, T Izawa, Y Maeda… - Annals of biomedical …, 2016 - Springer
Osteoporotic fracture has become a major public health problem, and until today, the
treatments available are not satisfactory. While there is growing evidence to support the …

The evaluation of therapeutic efficacy and safety profile of simvastatin prodrug micelles in a closed fracture mouse model

Y Zhang, Z Jia, H Yuan, A Dusad, K Ren, X Wei… - Pharmaceutical …, 2016 - Springer
Purpose To evaluate the therapeutic efficiency of a micellar prodrug formulation of
simvastatin (SIM/SIM-mPEG) and explore its safety in a closed femoral fracture mouse …

Evaluation of the effects of photobiomodulation on vertebras in two rat models of experimental osteoporosis

M Fredoni, M Ghatrehsamani, M Abdollahifar… - Lasers in Medical …, 2017 - Springer
The aim of this study was to evaluate the effects of photobiomodulation (PBM) on cancellous
bone in rat models of ovariectomized induced osteoporosis (OVX-D) and glucocorticoid …

Analysis of fracture healing in osteopenic bone caused by disuse: experimental study

AG Paiva, GR Yanagihara, AP Macedo… - Brazilian Journal of …, 2016 - SciELO Brasil
Osteoporosis has become a serious global public health issue. Hence, osteoporotic fracture
healing has been investigated in several previous studies because there is still controversy …

Animal models in bone research

DB Kimmel - Bone toxicology, 2017 - Springer
Many studies of the response of isolated osteoblasts and osteoclasts to treatments exist.
While such studies are informative, a reliable path to translating those effects into effects in …

经皮自体骨髓移植治疗胫骨骨折延迟愈合及不愈合的临床研究

周英勇, 程少文, 安涛, 陈克伟, 李红波, 彭磊 - 医学研究杂志, 2016 - yxyjzz.cn
目的探讨经皮自体骨髓移植治疗胫骨骨折延迟愈合, 不愈合的疗效. 方法按同一标准选取胫骨
骨折延迟愈合, 不愈合患者, 治疗组30 例, 对照组28 例, 治疗组采用经皮自体骨髓移植技术治疗 …

The effect of Aloe vera ethanolic extract in preventing ischemic-reperfusion injury during long bone fracture healing after tourniquet application: An animal …

TECJ Huwae, M Hidayat, H Sujuti… - F1000Research, 2022 - f1000research.com
Background: Tourniquet is a common instrument used in Orthopedics field to reduce blood
loss, providing a better operating field. One of the deleterious effects of tourniquet is …

[PDF][PDF] Mouse fracture models: a primer

B Qi, J Yu, Y Zhao, D Zhu, T Yu - Int J Clin Exp Med, 2016 - e-century.us
Mouse fracture models have become increasingly versatile tools for the study of how
fractures heal. Mouse genes can be specifically modified using transgenic technology …