Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Background. Circular RNA phosphorylase kinase regulatory subunit alpha 2 (circPHKA2;
hsa_circ_0090002) has a significantly, specifically different expression in acute ischemic …

Abstract Superoxide dismutase 2 (SOD2) catalyzes the dismutation of superoxide to
hydrogen peroxide in mitochondria, limiting mitochondrial damage. The SOD2 amino acid …

A quarter of a century ago, sickle cell disease (SCD) was mainly viewed as a typical genetic
disease inherited as a classical Mendelian trait. Therefore, the main focus concerning SCD …

Sickle cell anemia (SCA) is the most common cause of stroke in children. As it is a rare
disease, studies investigating the association with complications like stroke in SCD have …

Background Antioxidant genes, such as superoxide dismutase (SOD), catalase (CAT), and
nitric oxide synthase (NOS), play critical roles in spermatogenesis and sperm functions …

Background Oxidative stress plays a pivotal role in the pathophysiology of sickle cell
disease (SCD) and its associated disease complications. Superoxide Dismutases (SODs) …

Objectives Stroke is a devastating clinical outcome that significantly contributes to the
morbidity and mortality of sickle cell anemia (SCA) patients. Despite its advantages in …

Background: Sickle cell disease (SCD) is the commonest cause of stroke in children. As it is
a rare disease, studies investigating the association with complications like stroke in SCD …

Manganese superoxide dismutase-2 (SOD2) plays a crucial role in cells' protection against
mitochondrial oxidative damage. A genetic polymorphism in the mitochondrial targeting …