The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

Wnt/β-catenin signaling is an evolutionarily conserved, highly complex, key developmental
pathway that regulates cell fate, organ development, tissue homeostasis, as well as injury …

Podocytes are unique, highly specialized, terminally differentiated cells that are integral
components of the kidney glomerular filtration barrier. Podocytes are vulnerable to a variety …

Background & Aims Stearoyl-CoA desaturase (SCD) synthesizes monounsaturated fatty
acids (MUFAs) and has been associated with the development of metabolic syndrome …

Epithelial–mesenchymal transition (EMT) is a tightly regulated process by which epithelial
cells lose their hallmark epithelial characteristics and gain the features of mesenchymal …

Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that
unsolved inflammation will progressively transit into tissue fibrosis that finally results in an …

Diabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetes and is the
most common cause of end stage renal disease (ESRD). Renal fibrosis is the final …

Context Previous studies have implicated growth hormone (GH) in the progression of
several cancers, including breast, colorectal, and pancreatic. A mechanism by which GH …

Background Progression of CKD in type 2 diabetes, despite dual inhibition of sodium-
glucose transporter-2 and the renin-angiotensin system, remains a concern. Bromoindirubin …

Angiotensin II (Ang II) plays a pivotal role in promoting podocyte dysfunction and
albuminuria, however, the underlying mechanisms have not been fully delineated. In this …