The SLC8 gene family of sodium–calcium exchangers (NCX)–Structure, function, and regulation in health and disease

D Khananshvili - Molecular aspects of medicine, 2013 - Elsevier
The SLC8 gene family encoding Na+/Ca2+ exchangers (NCX) belongs to the CaCA
(Ca2+/Cation Antiporter) superfamily. Three mammalian genes (SLC8A1, SLC8A2, and …

Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions

D Khananshvili - Pflügers Archiv-European Journal of Physiology, 2014 - Springer
NCX proteins explore the electrochemical gradient of Na+ to mediate Ca 2+-fluxes in
exchange with Na+ either in the Ca 2+-efflux (forward) or Ca 2+-influx (reverse) mode …

Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1

J Xue, W Zeng, Y Han, S John, M Ottolia… - Nature …, 2023 - nature.com
Abstract Na+/Ca2+ exchangers (NCX) transport Ca2+ in or out of cells in exchange for Na+.
They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca2+ …

Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400

Y Dong, Z Yu, Y Li, B Huang, Q Bai, Y Gao… - The EMBO …, 2024 - embopress.org
Sodium-calcium exchanger proteins influence calcium homeostasis in many cell types and
participate in a wide range of physiological and pathological processes. Here, we elucidate …

[HTML][HTML] The cardiac Na+-Ca2+ exchanger: from structure to function

M Ottolia, S John, A Hazan… - Comprehensive …, 2021 - ncbi.nlm.nih.gov
Ca 2+ homeostasis is essential for cell function and survival. As such, the cytosolic Ca 2+
concentration is tightly controlled by a wide number of specialized Ca 2+ handling proteins …

Structural features of ion transport and allosteric regulation in sodium-calcium exchanger (NCX) proteins

M Giladi, I Tal, D Khananshvili - Frontiers in physiology, 2016 - frontiersin.org
Na+/Ca2+ exchanger (NCX) proteins extrude Ca2+ from the cell to maintain cellular
homeostasis. Since NCX proteins contribute to numerous physiological and …

[HTML][HTML] Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling

L Reilly, J Howie, K Wypijewski, MLJ Ashford… - The FASEB …, 2015 - ncbi.nlm.nih.gov
Abstract The electrogenic Na/Ca exchanger (NCX) mediates bidirectional Ca movements
that are highly sensitive to changes of Na gradients in many cells. NCX1 is implicated in the …

An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger

F Plain, SD Congreve, RSZ Yee, J Kennedy… - Journal of Biological …, 2017 - ASBMB
The electrogenic sodium/calcium exchanger (NCX) mediates bidirectional calcium transport
controlled by the transmembrane sodium gradient. NCX inactivation occurs in the absence …

Structural dynamics of Na+ and Ca2+ interactions with full-size mammalian NCX

M Giladi, L Fojtík, T Strauss, B Da'adoosh… - Communications …, 2024 - nature.com
Abstract Cytosolic Ca2+ and Na+ allosterically regulate Na+/Ca2+ exchanger (NCX)
proteins to vary the NCX-mediated Ca2+ entry/exit rates in diverse cell types. To resolve the …

Molecular determinants of pH regulation in the cardiac Na+–Ca2+ exchanger

S John, B Kim, R Olcese, JI Goldhaber… - Journal of General …, 2018 - rupress.org
The cardiac Na+–Ca2+ exchanger (NCX) plays a critical role in the heart by extruding Ca2+
after each contraction and thus regulates cardiac contractility. The activity of NCX is strongly …