Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling
molecules. This biological paradox underlies mechanisms that are important for the integrity …

Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2.
Mammalian cells express six Prx isoforms that are localized to various cellular …

Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control
cytokine-induced peroxide levels which mediate signal transduction in mammalian cells …

H2O2 production, protection, and signaling actions. Activation of various cell surface
receptors activates Nox situated either in the plasma membrane or in the membrane of …

It is well established that oxidative stress is an important cause of cell damage associated
with the initiation and progression of many diseases. Consequently, all air-living organisms …

The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems …

Eukaryotic 2-Cys peroxiredoxins (2-Cys Prxs) not only act as antioxidants, but also appear to
regulate hydrogen peroxide–mediated signal transduction. We showthat bacterial 2-Cys …

Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells
expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at …