The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

The Notch signaling pathway is an architecturally simple signaling mechanism, well known
for its role in cell fate regulation during organ development and in tissue homeostasis. In …

Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified
in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis …

The Notch signaling pathway is a critical player in embryogenesis but also plays various
roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations …

Notch and Wnt signaling are highly conserved intercellular communication pathways
involved in developmental processes, such as hematopoiesis. Even though data from …

Chronic lymphocytic leukemia (CLL) is caused by the accumulation of malignant B cells due
to a defect in apoptosis and the presence of small population of proliferating cells principally …

Chronic lymphocytic leukemia (CLL) cells extensively interact with and depend on their
surrounding tumor microenvironment (TME). The TME encompasses a heterogeneous array …

Mesenchymal stem cells (MSCs), multipotent stromal cells, have attracted extensive
attention in the field of regenerative medicine and cell therapy due to the capacity of self …