Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides

S Dissanayake, WA Denny, S Gamage… - Journal of Controlled …, 2017 - Elsevier
Efficient intracellular trafficking and targeted delivery to the site of action are essential to
overcome the current drawbacks of cancer therapeutics. Cell Penetrating Peptides (CPPs) …

Scorpion venom components as potential candidates for drug development

E Ortiz, GB Gurrola, EF Schwartz, LD Possani - Toxicon, 2015 - Elsevier
Scorpions are well known for their dangerous stings that can result in severe consequences
for human beings, including death. Neurotoxins present in their venoms are responsible for …

Cell penetration: scope and limitations by the application of cell‐penetrating peptides

S Reissmann - Journal of Peptide Science, 2014 - Wiley Online Library
The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

Scorpion venom components that affect ion-channels function

V Quintero-Hernández, JM Jiménez-Vargas… - Toxicon, 2013 - Elsevier
The number and types of venom components that affect ion-channel function are reviewed.
These are the most important venom components responsible for human intoxication …

Cell entry of cell penetrating peptides: tales of tails wagging dogs

AT Jones, EJ Sayers - Journal of Controlled Release, 2012 - Elsevier
Cell penetrating peptides hold considerable potential for academic and pharmaceutical
remits with an interest in delivering macromolecules to the insides of cells. Hundreds of …

A rational nomenclature for naming peptide toxins from spiders and other venomous animals

GF King, MC Gentz, P Escoubas, GM Nicholson - Toxicon, 2008 - Elsevier
Molecular toxinology research was initially driven by an interest in the small subset of animal
toxins that are lethal to humans. However, the realization that many venomous creatures …

Applications of cell-penetrating peptides for tumor targeting and future cancer therapies

J Regberg, A Srimanee, Ü Langel - Pharmaceuticals, 2012 - mdpi.com
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery.
One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide …

Diversity of folds in animal toxins acting on ion channels

S Mouhat, B Jouirou, A Mosbah, M De Waard… - Biochemical …, 2004 - portlandpress.com
Animal toxins acting on ion channels of excitable cells are principally highly potent short
peptides that are present in limited amounts in the venoms of various unrelated species …

New generation of cell‐penetrating peptides: functionality and potential clinical application

S Reissmann, MP Filatova - Journal of peptide science, 2021 - Wiley Online Library
Cell‐penetrating peptides (CPPs) can transport various cargoes through membranes of live
cells. Since the first generations of CPPs suffered from insufficient cell and tissue selectivity …

One scorpion, two venoms: Prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action

B Inceoglu, J Lango, J Jing, L Chen… - Proceedings of the …, 2003 - National Acad Sciences
Scorpion venom is a complex mixture of salts, small molecules, peptides, and proteins.
Scorpions employ this valuable tool in several sophisticated ways for subduing prey …