On the role of dysferlin in striated muscle: membrane repair, t‐tubules and Ca2+ handling

CJ Quinn, EJ Cartwright, AW Trafford… - The Journal of …, 2024 - Wiley Online Library
Dysferlin is a 237 kDa membrane‐associated protein characterised by multiple C2 domains
with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known …

Glucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux

T Seidel, DJ Fiegle, TJ Baur, A Ritzer, S Nay… - Basic research in …, 2019 - Springer
A major contributor to contractile dysfunction in heart failure is remodelling and loss of the
cardiomyocyte transverse tubular system (t-system), but underlying mechanisms and …

Functional consequences of changes in the distribution of Ca2+ extrusion pathways between t-tubular and surface membranes in a model of human ventricular …

M Pásek, M Bébarová, M Šimurdová… - Journal of Molecular and …, 2024 - Elsevier
The sarcolemmal Ca 2+ efflux pathways, Na+-Ca 2+-exchanger (NCX) and Ca 2+-ATPase
(PMCA), play a crucial role in the regulation of intracellular Ca 2+ load and Ca 2+ transient …

The origin of T-tubules

CJ Quinn, KM Dibb - Elife, 2023 - elifesciences.org
Skeletal Muscle: The origin of T-tubules | eLife Skip to Content eLife logo eLife home page Menu
Home Magazine Community About Search Alerts Submit your research Search by keyword …

Fraction of the t-tubular membrane as an important parameter in cardiac cellular electrophysiology: a new way of estimation

O Švecová, M Bébarová, M Šimurdová… - Frontiers in …, 2022 - frontiersin.org
The transverse-axial tubular system (t-tubules) plays an essential role in excitation-
contraction coupling in cardiomyocytes. Its remodelling is associated with various cardiac …

Atrial t-tubules adopt a specialist developmental state while alterations to Ca2+ buffering maintain systolic Ca2+ during postnatal development

CER Smith, JD Clarke, CJ Quinn, Z Sultan, H Najem… - bioRxiv, 2023 - biorxiv.org
Transverse (t)-tubules ensure a uniform rise in calcium (Ca2+) and thus contraction in
cardiac cells. Though more extensively studied in the ventricle, t-tubules also play a key role …

frontiers Frontiers in Physiology ORIGINAL RESEARCH published: 10 May 2022

G Caluori, M Frisk, TT Hong, M Bébarová… - … and applications in …, 2023 - books.google.com
The transverse-axial tubular system (t-tubules) plays an essential role in excitation-
contraction coupling of skeletal and cardiac myocytes by spreading depolarization from the …