Over the past decade, psychedelic compounds have emerged as potentially transformative
therapeutics for a variety of intractable neuropsychiatric conditions. However, historically …

Being different multifactorial forms of psychopathology, aggression, depression and suicidal
behavior, which is considered to be violent aggression directed against the self, have …

Background—Serotonergic medications with various mechanisms of action are used to treat
psychiatric disorders and are being investigated as treatments for drug dependence. The …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

A large number of 5-HT receptors (> 15) have been identified by molecular cloning
technology over the past 10 years. This review briefly summarizes available information …

The present survey compares the effects of antidepressants and their principal metabolites
on reuptake of biogenic amines and on receptor binding. The following antidepressants …

Rationale: The selective serotonin uptake inhibitor (SSRI) fluoxetine has been shown to not
only increase the extracellular concentrations of serotonin, but also dopamine and …

Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide.
Until now, treatments for depression have focused on the inhibition of monoaminergic …

Quantitative analysis of known drug–target interactions emerged in recent years as a useful
approach for drug repurposing and assessing side effects. In the present study, we present a …

Abstract Serotonin (5-HT) 2C receptors play an important role in the modulation of
monoaminergic transmission, mood, motor behaviour, appetite and endocrine secretion …