Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient
increase in their plasma membrane permeability, allowing transmembrane transport of …

Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Coarse-grained (CG) simulations have become an essential tool to study a large variety of
biomolecular processes, exploring temporal and spatial scales inaccessible to traditional …

Molecular permeation through lipid membranes is a fundamental biological process that is
important for small neutral molecules and drug molecules. Precise characterization of free …

Valvular heart diseases (VHDs) are currently treated using either mechanical or
bioprosthetic heart valves. Unfortunately, mechanical valves require lifelong anticoagulation …

Each biological cell, trillions of which build our bodies, is enveloped by its plasma
membrane. Composed largely of a bilayer (double layer) of lipids just two molecules thick …

This study introduces a new method for minimally invasive treatment of cancer—the ablation
of undesirable tissue through the use of irreversible electroporation. Electroporation is the …

Oral lipid-based drug delivery systems may include a broad range of oils, surfactants, and
cosolvents. This diversity makes comparison of lipid-based formulations difficult. Although …