Increasing attention has been paid to developability assessment with the understanding that
thorough evaluation of monoclonal antibody lead candidates at an early stage can avoid …

Antibody drugs should exhibit not only high-binding affinity for their target antigens but also
favorable physicochemical drug-like properties. Such drug-like biophysical properties are …

A new carboxyl-functionalized covalent organic framework (referred to as COF hereafter,
unless otherwise noted) contains aromatic backbones and carboxyl-functionalized …

Tangential flow filtration is an efficient membrane separation technology utilized across a
wide range of industries for separation and purification applications. The requirement of …

In this study the Single-Pass-Tangential-Flow-Filtration (SPTFF) concept for continuous
ultrafiltration in bioprocessing is investigated. Based on a previously validated physico …

Downstream processing is considered one of the most challenging phases of industrial
manufacturing of therapeutic proteins, accounting for a large portion of the total production …

There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …

The need to intensify downstream processing of monoclonal antibodies to complement the
advances in upstream productivity has led to increased attention toward implementing …

This manuscript proposes a general new framework for mathematical modeling, extended
sensitivity analysis and dynamic optimization of tangential flow filtration (TFF) systems for …

To achieve the high protein concentrations required for subcutaneous administration of
biologic therapeutics, numerous manufacturing process challenges are often encountered …