This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …

DNA that is transmitted to daughter cells must be accurately duplicated to maintain genetic
integrity and to promote genetic continuity. A major function of replicative DNA polymerases …

The information encoded in DNA is influenced by the presence of non-canonical
nucleotides, the most frequent of which are ribonucleotides. In this Review, we discuss …

The fidelity of DNA replication is determined by many factors, here simplified as the
contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch …

DNA polymerases synthesize DNA in only one direction, but large genomes require RNA
priming and bidirectional replication from internal origins. We review here the physical …

Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic
single-base damage that appear to have minimal effects on the helix. Since its discovery in …

The fidelity of DNA replication relies on three error avoidance mechanisms acting in series:
nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post …

In eukaryotes three DNA polymerases (Pols), α, δ, and ε, are tasked with bulk DNA synthesis
of nascent strands during genome duplication. Most evidence supports a model where Pol α …

Accurate DNA replication of an undamaged template depends on polymerase selectivity for
matched nucleotides, exonucleolytic proofreading of mismatches, and removal of remaining …

Alterations in the exonuclease domain of DNA polymerase ε (Polε) cause ultramutated
tumors. Severe mutator effects of the most common variant, Polε-P286R, modeled in yeast …