Computer-aided understanding and engineering of enzymatic selectivity
L Wu, L Qin, Y Nie, Y Xu, YL Zhao - Biotechnology Advances, 2022 - Elsevier
Abstract Enzymes offering chemo-, regio-, and stereoselectivity enable the asymmetric
synthesis of high-value chiral molecules. Unfortunately, the drawback that naturally …
synthesis of high-value chiral molecules. Unfortunately, the drawback that naturally …
The crystal structure of a biological insulated transmembrane molecular wire
A growing number of bacteria are recognized to conduct electrons across their cell
envelope, and yet molecular details of the mechanisms supporting this process remain …
envelope, and yet molecular details of the mechanisms supporting this process remain …
Structure-oriented engineering of amidase: modification of twisted access tunnel for efficient synthesis of 2-chloronicotinic acid
ZM Wu, F Xie, W Zheng, CF Liu, CP Lin, RC Zheng… - ACS …, 2023 - ACS Publications
Amidases are robust biocatalysts for the industrial synthesis of carboxylic acids. Amidase-
catalyzed hydrolysis of 2-chloronicotinamide is regarded as a promising route for 2 …
catalyzed hydrolysis of 2-chloronicotinamide is regarded as a promising route for 2 …
Visual analysis of biomolecular cavities: State of the art
In this report we review and structure the branch of molecular visualization that is concerned
with the visual analysis of cavities in macromolecular protein structures. First the necessary …
with the visual analysis of cavities in macromolecular protein structures. First the necessary …
Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
ClpXP is an ATP-dependent protease in which the ClpX AAA+ motor binds, unfolds, and
translocates specific protein substrates into the degradation chamber of ClpP. We present …
translocates specific protein substrates into the degradation chamber of ClpP. We present …
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels
A Rozenberg, I Kaczmarczyk, D Matzov… - Nature structural & …, 2022 - nature.com
Many organisms sense light using rhodopsins, photoreceptive proteins containing a retinal
chromophore. Here we report the discovery, structure and biophysical characterization of …
chromophore. Here we report the discovery, structure and biophysical characterization of …
Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1
Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids
in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and …
in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and …
Cryo-EM studies of TMEM16F calcium-activated ion channel suggest features important for lipid scrambling
As a Ca 2+-activated lipid scramblase and ion channel that mediates Ca 2+ influx,
TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood …
TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood …
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
YM Abbas, BT Laudenbach… - Proceedings of the …, 2017 - National Acad Sciences
IFIT1 (IFN-induced protein with tetratricopeptide repeats-1) is an effector of the host innate
immune antiviral response that prevents propagation of virus infection by selectively …
immune antiviral response that prevents propagation of virus infection by selectively …
Structural insights into the mechanism of the sodium/iodide symporter
The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates
active iodide (I−) transport into the thyroid gland, the first step in the biosynthesis of the …
active iodide (I−) transport into the thyroid gland, the first step in the biosynthesis of the …