Selenium is an essential dietary micronutrient. Ingested selenium is absorbed by the
intestines and transported to the liver where it is mostly metabolized to selenocysteine (Sec) …

Over half a century ago, DS Falconer first reported a mouse with a reeling gate. Four
decades later, the Reln gene was isolated and identified as the cause of the reeler …

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder in
which the aggregation and deposition of amyloid-β (Aβ) peptides in the brain are central to …

Clathrin-mediated endocytosis requires cargo-specific adaptor proteins that recognize
specific receptors and recruit them into coated pits. ARH [also called low-density lipoprotein …

Accumulation of extracellular amyloid β peptide (Aβ), generated from amyloid precursor
protein (APP) processing by β-and γ-secretases, is toxic to neurons and is central to the …

We have previously shown that the integral membrane protein CD317 has both a
conventional transmembrane domain near its N-terminus and a C-terminal glycosyl …

Fifty years have passed since the discovery of the first selenoprotein by Rotruck and
colleagues. In that time, the essential nature of selenium has come to light including the …

GABAA receptors (GABAA-Rs) play a significant role in mediating fast synaptic inhibition
and it is the main inhibitory receptor in the CNS. The role of Wnt signaling in coordinating …

Reelin, the protein defective in reeler mutant mice, plays a key role during brain
development. Reelin is processed proteolytically at two sites, and the central fragment …

Amyloid-β (Aβ) peptide accumulation in the brain is central to the pathogenesis of
Alzheimer's disease (AD). Aβ is produced through proteolytic processing of a …