Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Cancer divergence has many facets other than being considered a genetic term. It is a
tremendous challenge to understand the metastasis and therapy response in cancer …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for
the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head …

Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, and oxaliplatin,
have been widely used to treat a multitude of human cancers. However, a considerable …

(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …

Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …