Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …

Background Quality assurance (QA) and quality control (QC) are two quality management
processes that are integral to the success of metabolomics including their application for the …

Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …

Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations of
metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the …

Triple-negative breast cancer (TNBC) remains an unmet medical challenge. We investigated
metabolic dysregulation in TNBCs by using our multi-omics database (n= 465, the largest to …

While cost-effective high-throughput technologies provide an increasing amount of data, the
analyses of single layers of data seldom provide causal relations. Multi-omics data …

The resurgence of research into cancer metabolism has recently broadened interests
beyond glucose and the Warburg effect to other nutrients, including glutamine. Because …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Most patients with advanced triple-negative breast cancer (TNBC) develop drug resistance.
MYC and MCL1 are frequently co-amplified in drug-resistant TNBC after neoadjuvant …

Non-small cell lung cancer (NSCLC) is heterogeneous in the genetic and environmental
parameters that influence cell metabolism in culture. Here, we assessed the impact of these …