Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy
J Yao, M Yang, Y Duan - Chemical reviews, 2014 - ACS Publications
2. INTRODUCTION The investigation of many fundamental processes in life sciences
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …
RNAi therapeutics: principles, prospects and challenges
RNA interference (RNAi) was discovered less than a decade ago and already there are
human clinical trials in progress or planned. A major advantage of RNAi versus other …
human clinical trials in progress or planned. A major advantage of RNAi versus other …
Unlocking the potential of the human genome with RNA interference
The discovery of RNA interference (RNAi) may well be one of the transforming events in
biology in the past decade. RNAi can result in gene silencing or even in the expulsion of …
biology in the past decade. RNAi can result in gene silencing or even in the expulsion of …
Lipid-based systemic delivery of siRNA
RNAi technology has brought a new category of treatments for various diseases including
genetic diseases, viral diseases, and cancer. Despite the great versatility of RNAi that can …
genetic diseases, viral diseases, and cancer. Despite the great versatility of RNAi that can …
RNA interference: from gene silencing to gene-specific therapeutics
RKM Leung, PA Whittaker - Pharmacology & therapeutics, 2005 - Elsevier
In the past 4 years, RNA interference (RNAi) has become widely used as an experimental
tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an …
tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an …
Challenges and successes in developing new therapies for hepatitis C
R De Francesco, G Migliaccio - Nature, 2005 - nature.com
Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to
come because of the chronic nature of the infection, its high prevalence and the significant …
come because of the chronic nature of the infection, its high prevalence and the significant …
Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference
WB Tan, S Jiang, Y Zhang - Biomaterials, 2007 - Elsevier
Gene silencing using short interfering RNA (siRNA) is fast becoming an attractive approach
to probe gene function in mammalian cells. Although there have been some success in the …
to probe gene function in mammalian cells. Although there have been some success in the …
siRNA therapeutics: big potential from small RNAs
RNA interference (RNAi) is now an umbrella term referring to post-transcriptional gene
silencing mediated by either degradation or translation arrest of target RNA. This process is …
silencing mediated by either degradation or translation arrest of target RNA. This process is …
Small interfering RNA inhibits hepatitis B virus replication in mice
H Giladi, M Ketzinel-Gilad, L Rivkin, Y Felig… - Molecular Therapy, 2003 - cell.com
Current therapies for chronic hepatitis B virus (HBV) infection are limited in their effect on
viral gene expression and replication. Recent reports have shown that RNA interference can …
viral gene expression and replication. Recent reports have shown that RNA interference can …
Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions
S Schubert, A Grünweller, VA Erdmann… - Journal of molecular …, 2005 - Elsevier
Contradictory reports in the literature have emphasised either the sequence of small
interfering RNAs (siRNA) or the structure of their target molecules to be the major …
interfering RNAs (siRNA) or the structure of their target molecules to be the major …