The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …

Phosphatidylserine (PS) is a negatively charged glycerophospholipid found mainly in the
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …

Abstract SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …

Inflammasome complexes are pivotal in the innate immune response. The NLR family pyrin
domain containing protein 3 (NLRP3) inflammasome is activated in response to a broad …

The cGAS-STING pathway mediates cytoplasmic DNA-triggered innate immunity. STING
activation is initiated by cyclic-GMP-AMP (cGAMP)-induced translocation from the …

Membrane contact sites (MCSs) serve as a zone for nonvesicular lipid transport by oxysterol-
binding protein (OSBP)-related proteins (ORPs). ORPs mediate lipid countertransport, in …

Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate
and facilitate cellular functions. The formation of close contacts, termed “membrane contact …

The inter‐organelle transport of lipids must be regulated to ensure appropriate lipid
composition of each organelle. In mammalian cells, ceramide synthesised in the …

Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of
an autophagosome that degrades cellular cargo. However, recent studies have identified …

Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute one of the
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …