Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Microglia morphophysiological diversity and its implications for the CNS

A Vidal-Itriago, RAW Radford, JA Aramideh… - Frontiers in …, 2022 - frontiersin.org
Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central
nervous system (CNS) during the early stages of embryonic development. After colonizing …

Microglial regional heterogeneity and its role in the brain

YL Tan, Y Yuan, L Tian - Molecular psychiatry, 2020 - nature.com
Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …

Microglia emerge as central players in brain disease

MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

Microglia regulation of central nervous system myelin health and regeneration

SA Kent, VE Miron - Nature Reviews Immunology, 2024 - nature.com
Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Microbiome influences prenatal and adult microglia in a sex-specific manner

MS Thion, D Low, A Silvin, J Chen, P Grisel… - Cell, 2018 - cell.com
Microglia are embryonically seeded macrophages that contribute to brain development,
homeostasis, and pathologies. It is thus essential to decipher how microglial properties are …

Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Z Wang, WH Chen, SX Li, ZM He, WL Zhu, YB Ji… - Molecular …, 2021 - nature.com
Sleep deprivation (SD) is increasingly common in modern society, which can lead to the
dysregulation of inflammatory responses and cognitive impairment, but the mechanisms …

Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration

O Kann, F Almouhanna, B Chausse - Trends in neurosciences, 2022 - cell.com
Traditionally, lymphocytic interferon γ (IFN-γ) was considered to be a simple'booster'of
proinflammatory responses by microglia (brain-resident macrophages) during bacterial or …

Microglial subtypes: diversity within the microglial community

V Stratoulias, JL Venero, MÈ Tremblay… - The EMBO journal, 2019 - embopress.org
Microglia are brain‐resident macrophages forming the first active immune barrier in the
central nervous system. They fulfill multiple functions across development and adulthood …