Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Synaptic failure is an immediate cause of cognitive decline and memory dysfunction in
Alzheimer's disease. Dendritic spines are specialized structures on neuronal processes, on …

In Alzheimer disease (AD), deposition of neurofibrillary tangles and loss of synapses in the
neocortex and limbic system each correlate strongly with cognitive impairment. Tangles are …

The dendritic spines on pyramidal cells represent the main postsynaptic elements of cortical
excitatory synapses and they are fundamental structures in memory, learning and cognition …

A progressive loss of episodic memory is a well-known clinical symptom that characterizes
Alzheimer's disease (AD). The beginning of this loss of memory has been associated with …

Almost a 20% of the residues of tau protein are phosphorylatable amino acids: serine,
threonine, and tyrosine. In this paper we comment on the consequences for tau of being a …

The main pathological hallmarks in Alzheimer's disease (AD) are the presence of
extracellular amyloid plaques, primarily consisting of amyloid-β (Aβ) peptide, and the …

Dendritic spines are key components of a variety of microcircuits and they represent the
majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present …

Introduction We used an inducible mouse model expressing the Tau repeat domain with the
pro-aggregant mutation ΔK280 to analyze presynaptic Tau pathology in the hippocampus …

Oxidative stress with a depletion of glutathione is a key factor in the initiation and
progression of Alzheimer's disease (AD). N-Acetylcysteine (NAC), a glutathione precursor …