Glycosylation is one of the most common post-translational modifications of proteins that
affects their biological activity, solubility, and half-life. Therefore, its characterization is of …

A reliable, rapid, and effective bioanalytical method is essential for the determination of the
pharmacokinetic, pharmacodynamic, and toxicokinetic parameters that inform the safety and …

Different manufacturing processes and storage conditions of biotherapeutics can lead to a
significant variability in drug products arising from chemical and enzymatic post-translational …

The analysis of monoclonal antibodies glycosylation is a crucial quality control attribute of
biopharmaceutical drugs. High throughput screening approaches for antibody glycoform …

Modern analytical approaches employing high-resolution mass spectrometry (MS) facilitate
the generation of a vast amount of structural data of highly complex glycoproteins …

Background: The N-glycosylation profile as well as the subunit assembly of monoclonal
antibodies (mAbs) are strongly dependent on manufacturing conditions and thus need to be …

Nano-liquid chromatography (nanoLC) has proven itself as a powerful tool and its scope
entails various applications in (bio) analytical fields. Operation at low (nL/min) flow rates in …

Manganese ferrite nanoparticle (MnFe 2 O 4 NPs) has introduced a versatile platform to
develop a multifunctional nanosystem for Magnetic Resonance Imaging (MRI) and Single …

In recent years, advanced HPLC-MS strategies based on intact protein (“top-down”) or
protein subunit (“middle-up/middle-down”) analysis have been implemented for the …

We present the first use of a bioengineered mammalian transposase system derived from
Myotis lucifugus (bMLT) for integration of expression vectors into the CHO genome, focusing …