Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data
Parkinson's disease (PD) is a serious neurodegenerative disorder marked by significant
clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD …
clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD …
Deep phenotyping for precision medicine in Parkinson's disease
AK Schalkamp, N Rahman… - Disease Models & …, 2022 - journals.biologists.com
ABSTRACT A major challenge in medical genomics is to understand why individuals with
the same disorder have different clinical symptoms and why those who carry the same …
the same disorder have different clinical symptoms and why those who carry the same …
Data-driven discovery of movement-linked heterogeneity in neurodegenerative diseases
Neurodegenerative diseases manifest different motor and cognitive signs and symptoms
that are highly heterogeneous. Parsing these heterogeneities may lead to an improved …
that are highly heterogeneous. Parsing these heterogeneities may lead to an improved …
Subtyping of early-onset Parkinson's disease using cluster analysis: A large cohort study
Z Zhou, X Zhou, Y Xiang, Y Zhao, H Pan… - Frontiers in Aging …, 2022 - frontiersin.org
Background Increasing evidence suggests that early-onset Parkinson's disease (EOPD) is
heterogeneous in its clinical presentation and progression. Defining subtypes of EOPD is …
heterogeneous in its clinical presentation and progression. Defining subtypes of EOPD is …
MNCD: A new tool for classifying Parkinson's disease in daily clinical practice
D Santos García, M Álvarez Sauco, M Calopa… - Diagnostics, 2021 - mdpi.com
Background and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder
in which the symptoms and prognosis can be very different among patients. We propose a …
in which the symptoms and prognosis can be very different among patients. We propose a …
Parkinson's disease motor subtypes change with the progression of the disease: results from the COPPADIS cohort at 2-year follow-up
D Santos García, H Canfield… - Journal of …, 2022 - content.iospress.com
Background: Motor phenotype (MP) can be associated with a different prognosis in
Parkinson's disease (PD), but it is not fixed and can change over time. Objective: Our aim …
Parkinson's disease (PD), but it is not fixed and can change over time. Objective: Our aim …
Data-driven subtyping of Parkinson's using acoustic analysis of sustained vowels and cluster analysis: findings in the Parkinson's voice initiative study
People diagnosed with Parkinson's (PwP) exhibit a diverse manifestation of heterogeneous
symptoms which likely reflect different subtypes. However, there is no widely accepted …
symptoms which likely reflect different subtypes. However, there is no widely accepted …
Brain network centrality and connectivity are associated with clinical subtypes and disease progression in Parkinson's disease
Z Chen, C He, P Zhang, X Cai, X Li, W Huang… - Brain Imaging and …, 2024 - Springer
To investigate brain network centrality and connectivity alterations in different Parkinson's
disease (PD) clinical subtypes using resting-state functional magnetic resonance imaging …
disease (PD) clinical subtypes using resting-state functional magnetic resonance imaging …
[图书][B] A Robust Unified Graph Model Based on Molecular Data Binning for Subtype Discovery in High-dimensional Spaces
MSH Zada - 2023 - search.proquest.com
Abstract Machine learning (ML) is a subfield of artificial intelligence (AI) that has already
revolutionised the world around us. It is a widely employed process for discovering patterns …
revolutionised the world around us. It is a widely employed process for discovering patterns …
A Robust Unified Graph Model Based on Molecular Data Binning for Subtype Discovery in High-dimensional Spaces
M Hassan Zada - 2023 - repository.derby.ac.uk
Abstract Machine learning (ML) is a subfield of artificial intelligence (AI) that has already
revolutionised the world around us. It is a widely employed process for discovering patterns …
revolutionised the world around us. It is a widely employed process for discovering patterns …