Electroreductive Cross-Coupling Reactions: Carboxylation, Deuteration, and Alkylation

P Li, Y Wang, H Zhao, Y Qiu - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus Electrochemistry has been used as a tool to drive chemical reactions for more
than two centuries. With the help of an electrode and a power source, chemists are provided …

Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)

D Lehnherr, L Chen - Organic Process Research & Development, 2024 - ACS Publications
This review summarizes examples of organic electrosynthesis from the peer-reviewed
literature from 2000 to 2023 that have been conducted on scales of 20 g or above. A …

A Scalable Solution to Constant-Potential Flow Electrochemistry

JD Griffin, KC Harper… - … Process Research & …, 2024 - ACS Publications
The burgeoning interest in new electrochemical methods holds promise to provide a
plethora of strategic disconnections for pharmaceutical compounds that are safer, less …

The Future of Electro-organic Synthesis in Drug Discovery and Early Development

HR Stephen, JL Röckl - ACS Organic & Inorganic Au, 2024 - ACS Publications
Electro-organic chemistry presents a promising frontier in drug discovery and early
development, facilitating novel reactivity aligned with green chemistry principles. Despite …

Pushing the Limits of Organometallic Redox Chemistry with an Isolable Mn (− I) Dianion

A Karagiannis, H Neugebauer… - Journal of the …, 2024 - ACS Publications
We report an incredibly reducing and redox-active Mn–I dianion,[Mn (CO) 3 (Ph2B (t
BuNHC) 2)] 2–(NHC= N-heterocyclic carbene), furnished via 2e–reduction of the parent 16e …

Adoption of Electrochemistry within the Pharmaceutical Industry: Insights from an Industry-Wide Survey

AC Ferretti, B Cohen, L Deng, M Diwan… - … Process Research & …, 2025 - ACS Publications
This article presents the results of a comprehensive survey on the adoption of
electrochemistry among 17 major pharmaceutical companies. The study examined key …

Benchmarking Trisaminocyclopropeniums as Mediators for Anodic Oxidation Reactions

SN Carneiro, JD Laffoon, L Luo… - The Journal of Organic …, 2024 - ACS Publications
This report benchmarks a tris (amino) cyclopropenium (TAC) salt as an electron-transfer
mediator for anodic oxidation reactions in comparison to two known mediators: a …

Scalable Flow Electrosynthesis of Iminophosphoranes

D Lehnherr, L Chen, F Lévesque… - … Process Research & …, 2025 - ACS Publications
A scalable electrochemical process to synthesize iminophosphorane ligands is reported.
The application of these iminophosphoranes was recently reported in Ni-catalyzed cross …