Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

AKI is associated with high morbidity and mortality, and it predisposes to the development
and progression of CKD. Novel strategies that minimize AKI and halt the progression of CKD …

The innate immune system has been implicated in both AKI and CKD. Damaged
mitochondria release danger molecules, such as reactive oxygen species, DNA, and …

Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the
development of proteinuria in several glomerular diseases. Slit diaphragm should be a …

Renal ischemia is the most common cause of acute kidney injury (AKI) that might be
exacerbate lupus activity through neutrophil extracellular traps (NETs) and apoptosis. Here …

The aim of this study was to determine the protective effect of quercetin,
epigallocatechingallate, resveratrol, and rutin against the disruption of epithelial integrity …

Vitamin A (VA, retinol) and its metabolites (commonly called retinoids) are required for the
proper development of the kidney during embryogenesis, but retinoids also play key roles in …

Objective: In vivo studies suggest that intestinal barrier integrity is dependent on
mitochondrial ATP production. Here, we aim to provide mechanistic support, using an in vitro …

Kidney damage due to ischemia or rejection results in the accumulation of unfolded and
misfolded proteins in the endoplasmic reticulum (ER) lumen, a condition known as “ER …