COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …

Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways.
Recent research has displayed a deep interest in developing plant-based cancer …

Venous and arterial thromboses, called as cancer-associated thromboembolism (CAT), are
common complications in cancer patients that are associated with high mortality. The cell …

The rising incidence and persistent thrombosis in multiple cancers including those that are
immunosuppressive highlight the need for understanding the tumor coagulome system and …

The coagulation system is a part of the mammalian host defense system. Pathogens and
pathogen components, such as bacterial lipopolysaccharide (LPS), induce tissue factor (TF) …

Protein disulfide isomerase (PDI) and its superfamilies are mainly endoplasmic reticulum
(ER) resident proteins with essential roles in maintaining cellular homeostasis, via thiol …

Acute leukemia (AL) is a hematological malignancy with high morbidity and mortality that is
caused by abnormal hematopoietic stem cells. AL can change the parameters, quality, and …

Thiol isomerases, including PDI, ERp57, ERp5, and ERp72, play important and distinct roles
in cancer progression, cancer cell signaling, and metastasis. We recently discovered that …

Introduction Protein disulfide isomerase (PDI) contributes to tissue factor (TF) regulation in
monocytes. While bacitracin and quercetin-3-rutinoside mitigate myeloid TF production, the …

Although cancer-associated thrombosis (CAT) is a frequent complication in patients with
malignancies, its treatment remains a challenge in daily practice. Here, we report the clinical …