Traditional organic synthesis relies heavily on organic solvents for a multitude of tasks,
including dissolving the components and facilitating chemical reactions, because many …

The past decade has seen a substantial increase in successful examples of the combination
of chemo-and biocatalysis for multistep syntheses. This is driven by obvious advantages …

The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

The field of biocatalysis has advanced from harnessing natural enzymes to using directed
evolution to obtain new biocatalysts with tailor-made functions. Several tools have recently …

Artificial metalloenzymes (ArMs) result from the incorporation of an abiotic metal cofactor
within a protein scaffold. From the earliest techniques of transition metals adsorbed on silk …

The field of artificial metalloenzymes (ArMs) is rapidly growing and ArMs are attracting
increasing attention, for example, in the fields of biosensing and drug therapy. Protein …

Conspectus Artificial metalloenzymes (ArMs) result from anchoring a metal-containing
moiety within a macromolecular scaffold (protein or oligonucleotide). The resulting hybrid …

Conspectus In nature, heme cofactor-containing proteins participate not only in electron
transfer and O2 storage and transport but also in biosynthesis and degradation. The …

Conspectus The biotin–streptavidin technology offers an attractive means to engineer
artificial metalloenzymes (ArMs). Initiated over 50 years ago by Bayer and Wilchek, the biotin …

Conspectus Transition metal catalysts mediate a wide variety of chemo-, stereo-, and
regioselective transformations, and therefore play a pivotal role in modern synthetic organic …