The innate lymphoid cell (ILC) family is composed of natural killer (NK) cells, ILC1, ILC2 and
ILC3, which participate in immune responses to virus, bacteria, parasites and transformed …

Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of
spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and …

The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a
murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity …

Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly
as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within …

Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

Mast cell (MC) mediator release after crosslinking of surface-bound IgE antibody by ingested
antigen underlies food allergy. However, IgE antibodies are not uniformly associated with …

Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have been
implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s …

Innate lymphoid cells (ILC) are abundant in mucosal tissues. They serve critical functions in
anti-pathogen response and tissue homeostasis. However, the heterogenous composition of …