Biology and role of extracellular vesicles (EVs) in the pathogenesis of thrombosis

M Zarà, GF Guidetti, M Camera, I Canobbio… - International journal of …, 2019 - mdpi.com
Extracellular vesicles (EVs) are well-established mediators of cell-to-cell communication.
EVs can be released by every cell type and they can be classified into three major groups …

[HTML][HTML] P‐and E‐selectin in venous thrombosis and non‐venous pathologies

M Purdy, A Obi, D Myers, T Wakefield - Journal of Thrombosis and …, 2022 - Elsevier
Venous thromboembolism is a very common and costly health problem worldwide.
Anticoagulant treatment for VTE is imperfect: all have the potential for significant bleeding …

Extracellular vesicles and thrombosis: update on the clinical and experimental evidence

K Zifkos, C Dubois, K Schäfer - International Journal of Molecular …, 2021 - mdpi.com
Extracellular vesicles (EVs) compose a heterogenous group of membrane-derived particles,
including exosomes, microvesicles and apoptotic bodies, which are released into the …

Pathophysiology of coagulation and emerging roles for extracellular vesicles in coagulation cascades and disorders

H Al-Koussa, I AlZaim, ME El-Sabban - Journal of clinical medicine, 2022 - mdpi.com
The notion of blood coagulation dates back to the ancient Greek civilization. However, the
emergence of innovative scientific discoveries that started in the seventeenth century …

Extracellular vesicles as drivers of immunoinflammation in atherothrombosis

R Suades, MF Greco, T Padró, L Badimon - Cells, 2022 - mdpi.com
Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality all
over the world. Extracellular vesicles (EVs), small lipid-bilayer membrane vesicles released …

Liquid biopsies: microvesicles in cardiovascular disease

L Badimon, R Suades, A Vilella-Figuerola… - Antioxidants & Redox …, 2020 - liebertpub.com
Significance: Circulating microvesicles (cMV) are small (0.1–1 μm) phospholipid-rich blebs
released by almost all cell types, and their release increases with cell activation and injury …

[HTML][HTML] Plasma levels of platelet‐derived microvesicles are associated with risk of future venous thromboembolism

O Snir, L Wilsgård, N Latysheva, CJE Wahlund… - Journal of Thrombosis …, 2022 - Elsevier
Abstract Background Microvesicles (MVs) are small double‐membrane encapsulated
particles shed from cells. Case‐control studies have reported elevated plasma levels of …

Platelet microvesicles, inflammation, and coagulation markers: a pilot study

A Gidaro, AP Delitala, R Manetti, S Caccia… - Hematology …, 2023 - mdpi.com
Background: Platelet “Microvesicles”(MVs) are studied for their role in blood coagulation and
inflammation. The study aimed to establish if MVs are related to age, plasma levels of …

Metabolic landscape in venous thrombosis: insights into molecular biology and therapeutic implications

Z Cao, X Jiang, Y He, X Zheng - Annals of Medicine, 2024 - Taylor & Francis
The findings of the last decade suggest a complex link between inflammatory cells,
coagulation, and the activation of platelets and their synergistic interaction to promote …

[HTML][HTML] Complement activation assessed by the plasma terminal complement complex and future risk of venous thromboembolism

II Høiland, RA Liang, SK Brækkan, K Pettersen… - Journal of Thrombosis …, 2019 - Elsevier
Background It remains uncertain whether activation of the complement system, assessed by
the soluble terminal C5b‐9 complement complex (plasma TCC), is associated with future …