Major advances have occurred in recent years in our understanding of HIV-1 assembly,
release and maturation, as work in this field has been propelled forwards by developments …

Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

The mature capsids of HIV and other retroviruses organize and package the viral genome
and its associated enzymes for delivery into host cells. The HIV capsid is a fullerene cone: a …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in
CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart …

The detailed molecular interactions between native HIV-1 capsid protein (CA) hexamers that
shield the viral genome and proteins have been elusive. We report crystal structures …

The HIV-1 capsid is a fullerene cone made of quasi-equivalent hexamers and pentamers of
the viral CA protein. Typically, quasi-equivalent assembly of viral capsid subunits is …

Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant
strains continue to emerge, underscoring the need for additional novel mechanism inhibitors …

Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …

Human immunodeficiency virus type 1 (HIV-1) infection is dependent on the proper
disassembly of the viral capsid, or “uncoating,” in target cells. The HIV-1 capsid consists of a …