[HTML][HTML] Mechanisms of intergenerational transmission of polycystic ovary syndrome

DA Dumesic, LR Hoyos, GD Chazenbalk… - …, 2020 - rep.bioscientifica.com
Developmental origins of adult disease (DoHAD) refers to critical gestational ages during
human fetal development and beyond when the endocrine-metabolic status of the mother …

Mediation of vertebrate life histories via insulin‐like growth factor‐1

B Dantzer, EM Swanson - Biological Reviews, 2012 - Wiley Online Library
Life‐history traits describe parameters associated with growth, size, survival, and
reproduction. Life‐history variation is a hallmark of biological diversity, yet researchers …

Maternal bisphenol-A levels at delivery: a looming problem?

V Padmanabhan, K Siefert, S Ransom… - Journal of …, 2008 - nature.com
Objective: The objective was to determine whether bisphenol-A (BPA) is found in maternal
circulation of pregnant women in the US population and is related to gestational length and …

Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport

K Sathishkumar, R Elkins, V Chinnathambi… - Reproductive Biology …, 2011 - Springer
Background Exposure of pregnant mothers to elevated concentrations of circulating
testosterone levels is associated with fetal growth restriction and delivery of small-for …

Androgen Stimulates Growth of Mouse Preantral Follicles In Vitro: Interaction With Follicle-Stimulating Hormone and With Growth Factors of the TGFβ Superfamily

M Laird, K Thomson, M Fenwick, J Mora… - …, 2017 - academic.oup.com
Androgens are essential for the normal function of mature antral follicles but also have a role
in the early stages of follicle development. Polycystic ovary syndrome (PCOS), the most …

Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep

A Veiga-Lopez, TL Steckler, DH Abbott… - Biology of …, 2011 - academic.oup.com
Prenatal testosterone excess in sheep leads to reproductive and metabolic disruptions that
mimic those seen in women with polycystic ovary syndrome. Comparison of prenatal …

Effect of maternal PCOS and PCOS-like phenotype on the offspring's health

M Puttabyatappa, RC Cardoso… - Molecular and cellular …, 2016 - Elsevier
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with both
reproductive and metabolic abnormalities affecting women of reproductive age. While the …

Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney

CY Li, A Basit, A Gupta, Z Gáborik, E Kis… - The Journal of steroid …, 2019 - Elsevier
Testosterone glucuronide (TG), androsterone glucuronide (AG), etiocholanolone
glucuronide (EtioG) and dihydrotestosterone glucuronide (DHTG) are the major metabolites …

Developmental programming of hypertension: insight from animal models of nutritional manipulation

NB Ojeda, D Grigore, BT Alexander - Hypertension, 2008 - Am Heart Assoc
States today. The risk for LBW is greater within the black population than the white, with a
greater percentage of LBW occurring within the southern United States relative to other parts …

Sex-specific differences and developmental programming for diseases in later life

DP Sundrani, SS Roy, AT Jadhav… - Reproduction, Fertility …, 2017 - CSIRO Publishing
Epidemiological data indicate that developmental programming of various non-
communicable diseases (NCDs) occurs as a consequence of altered maternal metabolic …