Cancer is one of the leading causes of human death worldwide. Treatment of cancer
exhausts significant medical resources, and the morbidity and mortality caused by cancer is …

Rolling circle replication (RCR), including rolling circle amplification (RCA) and rolling circle
transcription (RCT), is an isothermal enzymatic reaction. Because of its high amplification …

CRISPR/Cas9 is emerging as a platform for gene therapeutics, and the treatment efficiency
is expected to be enhanced by combination with other therapeutic agents. Herein, we report …

Taking advantage of cancer cells' endogenous characters, the responsive activation of DNA
nanomachines has achieved great success in tumor therapy. Combining with extra stimuli …

In recent years, DNA has been widely noted as a kind of material that can be used to
construct building blocks for biosensing, in vivo imaging, drug development, and disease …

The transport, enrichment, and purification of nanoparticles are fundamental activities in the
fields of biology, chemistry, material science, and medicine. Here, we demonstrate an …

Taking advantage of the excellent trans-cleavage activity, CRISPR-based diagnostics
(CRISPR-Dx) has shown great promise in molecular diagnostics. However, the single …

Nanomedicines offer nanoscale drug delivery system. They offer ways of promising drug
transportation, and address the issues of lack of targeting and permeability of traditional …

Photodynamic therapy (PDT) is considered as an emerging therapeutic modality against
cancer with high spatiotemporal selectivity because the utilized photosensitizers (PSs) are …

Herein, we report a CRISPR/Cas12a-assisted chemiluminescence sensor for aflatoxin B1
(AFB1) detection based on functional nucleic-acid-mediated target recognition and in-pipet …