Charcot described amyotrophic lateral sclerosis (ALS) in 1874. Despite progress, this
creeping paralysis, known colloquially as Lou Gehrig's disease, is still not visibly affected by …

The diaphragm is the main inspiratory muscle, and its dysfunction can lead to significant
adverse clinical consequences. The aim of this review is to provide clinicians with an …

Background Few patients with amyotrophic lateral sclerosis currently receive non-invasive
ventilation (NIV), reflecting clinical uncertainty about the role of this intervention. We aimed …

Background Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is a
fatal neurodegenerative disease. Neuromuscular respiratory failure is the most common …

Background: Noninvasive ventilation (NIV) probably improves survival in ALS, but the
magnitude and duration of any improvement in quality of life (QoL) and the optimal criteria …

Increasing numbers of patients are surviving episodes of prolonged mechanical ventilation
or benefitting from the recent availability of user‐friendly noninvasive ventilators. Although …

Die außerklinische Beatmung über einen invasiven oder nichtinvasiven Beatmungszugang
ist mittlerweile etablierter Standard. Entsprechend wurde bereits im Jahr 2010 unter der …

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease inevitably leading
to generalized muscle weakness and premature death. Sleep disturbances are extremely …

Background Non-invasive ventilation (NIV) is an efficient method for treating respiratory
failure in patients with amyotrophic lateral sclerosis (ALS). However, it requires a process of …

There is still no consensus as to which physiologic marker should be used as a trigger for
the initiation of non-invasive positive pressure ventilation (NPPV) in patients with …