Fundamental importance of ionic interactions in the liquid phase: A review of recent studies of ionic liquids in biomedical and pharmaceutical applications
KS Egorova, VP Ananikov - Journal of Molecular Liquids, 2018 - Elsevier
In recent years, research on ions and ionic interactions in solution has become a leading
scientific direction, and this advance has been especially pronounced in the field of ionic …
scientific direction, and this advance has been especially pronounced in the field of ionic …
State-of-the-art and novel approaches to mild solubilization of inclusion bodies
R Klausser, J Kopp, E Prada Brichtova… - … in Bioengineering and …, 2023 - frontiersin.org
Throughout the twenty-first century, the view on inclusion bodies (IBs) has shifted from
undesired by-products towards a targeted production strategy for recombinant proteins …
undesired by-products towards a targeted production strategy for recombinant proteins …
Strategic planning of proteins in ionic liquids: future solvents for the enhanced stability of proteins against multiple stresses
Ionic liquids (ILs) present a vast number of solvents capable of replacing toxic organic
solvents in chemical, biotechnology and biomedical applications. ILs are inexpensive and …
solvents in chemical, biotechnology and biomedical applications. ILs are inexpensive and …
Microscopic structural features of water in aqueous–reline mixtures of varying compositions
Reline, a mixture of urea and choline chloride in a 2: 1 molar ratio, is one of the most
frequently used deep eutectic solvents. Pure reline and its aqueous solution have large …
frequently used deep eutectic solvents. Pure reline and its aqueous solution have large …
Choline Chloride as a Nano‐Crowder Protects HP‐36 from Urea‐Induced Denaturation: Insights from Solvent Dynamics and Protein‐Solvent Interactions
Urea at sufficiently high concentration unfolds the secondary structure of proteins leading to
denaturation. In contrast, choline chloride (ChCl) and urea, in 1: 2 molar ratio, form a deep …
denaturation. In contrast, choline chloride (ChCl) and urea, in 1: 2 molar ratio, form a deep …
Counteraction Effects of Ammonium-Based Ionic Liquids on Urea-Induced Denaturation of α-Lactalbumin: A Comprehensive Molecular Simulation Study
KP Ghanta, S Bandyopadhyay - The Journal of Physical Chemistry …, 2023 - ACS Publications
Ionic liquids (ILs) are known to stabilize protein conformations in aqueous medium.
Importantly, ILs can also act as refolding additives in urea-driven denaturation of proteins …
Importantly, ILs can also act as refolding additives in urea-driven denaturation of proteins …
Implications of imidazolium-based ionic liquids as refolding additives for urea-induced denatured serum albumins
One of the major challenges in protein stability is that proteins can easily unfold in the
presence of denaturants like urea, which alters the native structure of proteins. There are …
presence of denaturants like urea, which alters the native structure of proteins. There are …
Preferential binding of urea to single-stranded DNA structures: a molecular dynamics study
EA Oprzeska-Zingrebe, J Smiatek - Biophysical journal, 2018 - cell.com
In nature, a wide range of biological processes such as transcription termination and
intermolecular binding depend on the formation of specific DNA secondary and tertiary …
intermolecular binding depend on the formation of specific DNA secondary and tertiary …
Protein packaging in ionic liquid mixtures: an ecofriendly approach towards the improved stability of β-lactoglobulin in cholinium-based mixed ionic liquids
Ionic liquid (IL)–protein interaction studies are well documented; nonetheless, some families
of ILs possess high toxicity which leads to the perturbation of biomolecules. However, ILs …
of ILs possess high toxicity which leads to the perturbation of biomolecules. However, ILs …
Ammonium based stabilizers effectively counteract urea-induced denaturation in a small protein: insights from molecular dynamics simulations
Room temperature ionic liquids (IL) and deep eutectic solvents (DES) are known to aid the
conformational stability and activity of proteins and enzymes in aqueous solutions. They are …
conformational stability and activity of proteins and enzymes in aqueous solutions. They are …