The effects of air pollution on the brain: a review of studies interfacing environmental epidemiology and neuroimaging

P de Prado Bert, EMH Mercader, J Pujol… - Current environmental …, 2018 - Springer
Abstract Purpose of Review An emerging body of evidence has raised concern regarding
the potentially harmful effects of inhaled pollutants on the central nervous system during the …

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

DS Harischandra, D Rokad, ML Neal, S Ghaisas… - Science …, 2019 - science.org
The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of
certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a …

Trace Elements and Cognitive Function in Adults and Older Adults: A Comprehensive Systematic Review

B Gerardo, J Nogueira, MC Pinto, A Almeida… - Exposure and …, 2024 - Springer
Dysregulation of trace elements (TE) homeostasis can affect normal neurotransmission and
lead to neurodegeneration, which frequently manifests as cognitive deterioration …

Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and …

MR Langley, S Ghaisas, M Ay, J Luo, BN Palanisamy… - Neurotoxicology, 2018 - Elsevier
Parkinson's disease (PD) is now recognized as a neurodegenerative condition caused by a
complex interplay of genetic and environmental influences. Chronic manganese (Mn) …

Synergy as a new and sensitive marker of basal ganglia dysfunction: A study of asymptomatic welders

MM Lewis, EY Lee, HJ Jo, G Du, J Park, MR Flynn… - Neurotoxicology, 2016 - Elsevier
Background Multi-digit synergies, a recently developed, theory-based method to quantify
stability of motor action, are shown to reflect basal ganglia dysfunction associated with …

Derivation of an occupational exposure level for manganese in welding fumes

LA Bailey, LE Kerper, JE Goodman - Neurotoxicology, 2018 - Elsevier
Exposure to high levels of manganese (Mn) in occupational settings is known to lead to
adverse neurological effects. Since Mn is an essential nutrient, there are mechanisms that …

Welding-related brain and functional changes in welders with chronic and low-level exposure

EY Lee, MR Flynn, MM Lewis, RB Mailman, X Huang - Neurotoxicology, 2018 - Elsevier
Although an essential nutrient, manganese (Mn) can be toxic at high doses. There is,
however, uncertainty regarding the effects of chronic low-level Mn-exposure. This review …

[HTML][HTML] The effects of occupational exposure to manganese fume on neurobehavioral and neurocognitive functions: An analytical cross-sectional study among …

Y Mehrifar, M Bahrami, E Sidabadi, H Pirami - EXCLI journal, 2020 - ncbi.nlm.nih.gov
This study aimed to measure concentrations of manganese fume in breathing zone (BZ) and
blood among welders to assess neurocognitive and neurobehavioral functions among them …

PI3K/Akt signaling pathway ameliorates oxidative stress-induced apoptosis upon manganese exposure in PC12 cells

Y Tan, H Cheng, C Su, P Chen, X Yang - Biological Trace Element …, 2022 - Springer
Manganese (Mn)-induced neurotoxicity has aroused public concerns for many years, but its
precise mechanism is still poorly understood. Herein, we report the impacts of the …

Association of exposure to manganese and iron with striatal and thalamic GABA and other neurometabolites—Neuroimaging results from the WELDOX II study

S Casjens, U Dydak, S Dharmadhikari, A Lotz… - Neurotoxicology, 2018 - Elsevier
Objective Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify
neurometabolite concentrations in the brain. Within the framework of the WELDOX II study …