How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond

J Rimando, SR McCurdy, L Luznik - Blood, 2023 - ashpublications.org
Advances in conditioning, graft-versus-host disease (GVHD) prophylaxis and antimicrobial
prophylaxis have improved the safety of allogeneic hematopoietic cell transplantation (HCT) …

Advances in management for older adults with hematologic malignancies

AE Rosko, R Cordoba, G Abel, A Artz… - Journal of Clinical …, 2021 - ascopubs.org
Hematologic malignancies (HMs) represent a varied set of diseases ranging from indolent to
aggressive that are increasingly common in the growing older adult population …

A Study of Physical Resilience and Aging (SPRING): conceptual framework, rationale, and study design

J Walston, R Varadhan, QL Xue, B Buta… - Journal of the …, 2023 - Wiley Online Library
Understanding the physiological basis of physical resilience to clinical stressors is crucial for
the well‐being of older adults. This article presents a novel framework to discover the …

Recipient clonal hematopoiesis in allogeneic bone marrow transplantation for lymphoid malignancies

PH Imus, S Pasca, HL Tsai, YM Aljawai… - Blood …, 2024 - ashpublications.org
Allogeneic blood and marrow transplantation (alloBMT) is increasingly being used in older
patients with blood cancer. Aging is associated with an increasing incidence of clonal …

Preconditioning frailty phenotype influences survival and relapse for older allogeneic transplantation recipients

AD Sung, T Koll, SH Gier, A Racioppi, G White… - … and Cellular Therapy, 2024 - Elsevier
Hematologic malignancies disproportionately affect older adults. Hematopoietic cell
transplantation (HCT) is potentially curative, but poor overall survival (OS) has limited its use …

Peripheral blood haploidentical hematopoietic cell transplantation for patients aged 70 years and over with acute myeloid leukemia or high-risk myelodysplastic …

S Harbi, L Brac de la Perriere, B Bouchacourt… - Bone Marrow …, 2024 - nature.com
Haploidentical stem cell transplantation (Haplo-SCT) using non-myeloablative conditioning
regimen (NMAC) has extended the feasibility of allogeneic transplantation, notably in older …

Current status and perspectives of allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia

S Servais, Y Beguin, F Baron - Stem Cells Translational …, 2022 - academic.oup.com
As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best
chance for durable remission in older patients (≥ 60 years) with acute myeloid leukemia …

[HTML][HTML] PTCY and tacrolimus for GVHD prevention for older adults undergoing HLA-matched sibling and unrelated donor AlloHCT

MQ Salas, P Charry, A Pedraza… - … and Cellular Therapy, 2022 - Elsevier
The use of post-transplantation cyclophosphamide (PTCY) for graft-versus-host disease
(GHVD) prevention is becoming prevalent in the transplantation community when HLA …

[HTML][HTML] Cellular therapies in older adults with hematological malignancies: A case-based, state-of-the-art review

NR Neuendorff, A Khan, F Ullrich, S Yates… - Journal of Geriatric …, 2024 - Elsevier
Cellular therapies, including autologous stem cell transplant (ASCT), allogeneic
hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor-(CAR-) T cell …

Emerging approaches to improve allogeneic hematopoietic cell transplantation outcomes for nonmalignant diseases

Z DeFilipp, M Hefazi, YB Chen… - Blood, The Journal of …, 2022 - ashpublications.org
Many congenital or acquired nonmalignant diseases (NMDs) of the hematopoietic system
can be potentially cured by allogeneic hematopoietic cell transplantation (HCT) with varying …