Targeting the PI3K/AKT/mTOR signaling pathway in the treatment of human diseases: Current status, trends, and solutions

J Huang, L Chen, J Wu, D Ai, JQ Zhang… - Journal of medicinal …, 2022 - ACS Publications
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …

Advances in the activity evaluation and cellular regulation pathways of food-derived antioxidant peptides

R Lv, Y Dong, Z Bao, S Zhang, S Lin, N Sun - Trends in Food Science & …, 2022 - Elsevier
Background Oxidative stress is the main reason for inducing cell apoptosis, tissue damage
and pathological changes in the body. Antioxidants can be taken to eliminate radicals and …

Natural dietary supplementation of anthocyanins via PI3K/Akt/Nrf2/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse …

T Ali, T Kim, SU Rehman, MS Khan, FU Amin… - Molecular …, 2018 - Springer
Well-established studies have shown an elevated level of reactive oxygen species (ROS)
that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal …

Autophagy and apoptosis cascade: which is more prominent in neuronal death?

R Gupta, RK Ambasta, P Kumar - Cellular and molecular life sciences, 2021 - Springer
Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

mTOR signaling disruption and its association with the development of autism spectrum disorder

SD Thomas, NK Jha, S Ojha, B Sadek - Molecules, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by impairments in social interaction and communication along with repetitive stereotypic …

Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration

S Fakhri, A Iranpanah, MM Gravandi, SZ Moradi… - Phytomedicine, 2021 - Elsevier
Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

[HTML][HTML] CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease

Q Cheng, J Wang, M Li, J Fang, H Ding, J Meng… - Redox biology, 2022 - Elsevier
As a novel type of non-coding RNAs, covalently closed circular RNAs (circRNAs) are
ubiquitously expressed in eukaryotes. Emerging studies have indicated that dysregulation of …

Chitosan/TiO2 composite membrane improves proliferation and survival of L929 fibroblast cells: Application in wound dressing and skin regeneration

SS Behera, U Das, A Kumar, A Bissoyi… - International Journal of …, 2017 - Elsevier
The microbial infection and growth of fibroblasts are the critical factors for the effective
wound healing. The natural polymer-based dressing membranes may mimic extracellular …

Autophagy in age‐related macular degeneration: a regulatory mechanism of oxidative stress

ZY Zhang, XL Bao, YY Cong, B Fan… - Oxidative medicine and …, 2020 - Wiley Online Library
Age‐related macular degeneration (AMD) is a leading cause of severe visual loss and
irreversible blindness in the elderly population worldwide. Retinal pigment epithelial (RPE) …

On the neuroprotective effects of naringenin: pharmacological targets, signaling pathways, molecular mechanisms, and clinical perspective

Z Nouri, S Fakhri, FF El-Senduny, N Sanadgol… - Biomolecules, 2019 - mdpi.com
As a group of progressive, chronic, and disabling disorders, neurodegenerative diseases
(NDs) affect millions of people worldwide, and are on the rise. NDs are known as the …