Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motoneurons
and degradation of the neuromuscular junctions (NMJ). Consistent with the dying-back …

Microglia are resident immune cells of the CNS that are activated by infection, neuronal
injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of …

Microglia mediate multiple facets of neuroinflammation, including cytotoxicity, repair,
regeneration, and immunosuppression due to their ability to acquire diverse activation …

Inflammation is a common neuropathological feature in several neurological disorders,
including amyotrophic lateral sclerosis (ALS). We have studied the contribution of CSF1R …

Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline
with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus …

Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key
signaling steps of innate immune activation hence represent promising therapeutic targets …

Injury to the nervous system causes the almost immediate release of cytokines by glial cells
and neurons. These cytokines orchestrate a complex array of responses leading to …

Under the guidance of Ramón y Cajal, a plethora of students flourished and began to apply
his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease primarily
characterized by loss of motor neurons in brain and spinal cord. The death of motor neurons …