Laboratory animal models play an important role in the study of human diseases. Using
appropriate animals is critical not only for basic research but also for the development of …

The translation of novel discoveries from basic research to clinical application is a long,
often inefficient, and thus costly process. Accordingly, the process of drug development …

The ability to introduce foreign genes into the germ line and the successful expression of the
inserted gene in the organism have allowed the genetic manipulation of animals on an …

Genetic engineering of livestock is expected to have a major effect on the agricultural
industry. However, accurate assessment of the consequences of transgene expression is …

We have combined gene transfer, by microinjection, with 'in vitro'embryo production
technology, enabling us to carry out non-surgical transfer, to recipient cows, of microinjected …

Transgenic pigs are promising donor organisms for xenotransplantation as they share many
anatomical and physiological characteristics with humans. The most profound barrier to pig …

The worldwide prevalence of diabetes mellitus and obesity is rapidly increasing not only in
adults but also in children and adolescents. Diabetes is associated with macrovascular …

The in vitro production of porcine embryos has presented numerous challenges to
researchers over the past four decades. Some of the problems encountered were specific to …

Genetically modified laboratory animals provide a powerful approach for studying gene
expression and regulation and allow one to directly examine structure-function and cause …

Amid the explosion of fundamental knowledge generated from transgenic animal models, a
small group of scientists has been producing transgenic livestock with goals of improving …