Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …

Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Abstract The metabolite 2-hydroxyglutarate (2HG) can be produced as either a dR-or lS-
enantiomer, each of which inhibits α-ketoglutarate (αKG)-dependent enzymes involved in …

Background Lysine succinylation is an emerging posttranslational modification that has
garnered increased attention recently, but its role in gastric cancer (GC) remains …

Although much insight has been gained into the mechanisms by which activation of the
inflammasome can trigger pyroptosis in mammalian cells, the precise kinetics of the end …

The demand for glucose uptake and the accompanying enhanced glycolytic energy
metabolism is one of the most important features of cancer cells. Unlike the aerobic …

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide.
Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming …

In recent years, small molecule inhibition of LDHA (Lactate Dehydrogenase A) has evolved
as an appealing option for anticancer therapy. LDHA catalyzes the interconversion of …

Female middle age is characterized by a decline in skeletal muscle mass and performance,
predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they …