The glutathione transferase (GST) system of parasites represents the main detoxification
mechanism of hydrophobic and electrophilic compounds. Parasites lack the CYP450 …

Anthelminthics remain the only accessible means in the struggle against helminth parasites,
which cause significant morbidity and mortality in man and farm animals. The treatment of …

Helminth infections and allergy have evolutionary and clinical links. Infection with the
nematode Ascaris lumbricoides induces IgE against several molecules including …

BACKGROUND: The extensive similarities between helminth proteins and allergens are
thought to contribute to helminth-driven allergic sensitization. OBJECTIVE: The objective of …

Onchocerciasis is a debilitating neglected tropical disease caused by infection with the
filarial parasite Onchocerca volvulus. Adult worms live in subcutaneous tissues and produce …

Proteins are molecular devices, in the nanometer scale, where biological function is exerted
(1). They are the building blocks of all cells in our bodies and in all living creatures of all …

Homology is a fundamental concept in comparative biology and a crucial tool for the
analysis of character distribution. Introduced by Owen in 1843 (Lectures on comparative …

Sustainable control of human filariasis would benefit enormously from the development of
an effective vaccine. The ability to vaccinate experimental animals, with reductions in worm …

Glutathione S‒transferases (GSTs) play an important role in the detoxification of
xenobiotics. They catalyze the nucleophilic addition of glutathione (GSH) to nonpolar …

The diseases caused by parasitic nematodes in domestic and companion animals are major
factors that decrease production and quality of the agricultural products. Methods available …