Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

The endoplasmic reticulum (ER) plays a vital function in maintaining cellular homeostasis.
Endoplasmic reticulum stress (ERS) can trigger various modes of cell death by activating the …

Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, pioglitazone, is used
clinically to improve the glycemic state in patients with type-2 diabetes mellitus. Independent …

Stroke is one of the major causes of death and long-term disability, of which acute ischemic
stroke (AIS) is the most common type. Although circular RNA (circRNA) expression profiles …

Background: Prolonged endoplasmic reticulum stress has been identified in various
diseases. Inflammatory mediators, which have been shown to induce endoplasmic reticulum …

The average lifespan of humans has been increasing, resulting in a rapidly rising
percentage of older individuals and high morbidity of aging-associated diseases, especially …

Aims Exposure to maternal diabetes is associated with increased prevalence of
hypertension in the offspring. The mechanisms underlying the prenatal programming of …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) leads to premature stroke and vascular dementia …

Despite the advances made in cardiovascular disease prevention, there is still substantial
residual risk of adverse cardiovascular events. Contemporary evidence suggests that …