Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science

MD Rand, JM Tennessen, TFC Mackay… - Current …, 2023 - Wiley Online Library
The use of Drosophila melanogaster for studies of toxicology has grown considerably in the
last decade. The Drosophila model has long been appreciated as a versatile and powerful …

Charting the genotype–phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel

TFC Mackay, W Huang - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Understanding the genetic architecture (causal molecular variants, their effects, and
frequencies) of quantitative traits is important for precision agriculture and medicine and …

Genetics on the Fly: A Primer on the Drosophila Model System

KG Hales, CA Korey, AM Larracuente, DM Roberts - Genetics, 2015 - academic.oup.com
Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of …

JE Crawford, JM Alves, WJ Palmer, JP Day, M Sylla… - BMC biology, 2017 - Springer
Abstract Background The mosquito Aedes aegypti is the main vector of dengue, Zika,
chikungunya and yellow fever viruses. This major disease vector is thought to have arisen …

The foraging Gene and Its Behavioral Effects: Pleiotropy and Plasticity

I Anreiter, MB Sokolowski - Annual review of genetics, 2019 - annualreviews.org
The Drosophila melanogaster foraging (for) gene is a well-established example of a gene
with major effects on behavior and natural variation. This gene is best known for underlying …

OXR1 maintains the retromer to delay brain aging under dietary restriction

KA Wilson, S Bar, EB Dammer, EM Carrera… - Nature …, 2024 - nature.com
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified
polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd …

Evolution of reproductive behavior

RRH Anholt, P O'Grady, MF Wolfner, ST Harbison - Genetics, 2020 - academic.oup.com
Behaviors associated with reproduction are major contributors to the evolutionary success of
organisms and are subject to many evolutionary forces, including natural and sexual …

Integrating gene expression data into genomic prediction

Z Li, N Gao, JWR Martini, H Simianer - Frontiers in genetics, 2019 - frontiersin.org
Gene expression profiles potentially hold valuable information for the prediction of breeding
values and phenotypes. In this study, the utility of transcriptome data for phenotype …

Origins of knowledge: Insights from precocial species

E Versace, G Vallortigara - Frontiers in Behavioral Neuroscience, 2015 - frontiersin.org
Behavioral responses are influenced by knowledge acquired during the lifetime of an
individual and by predispositions transmitted across generations. Establishing the origin of …

A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure

S Zhou, SE Luoma, GE St. Armour, E Thakkar… - PLoS …, 2017 - journals.plos.org
The genetic factors that give rise to variation in susceptibility to environmental toxins remain
largely unexplored. Studies on genetic variation in susceptibility to environmental toxins are …