Current and future colorectal cancer screening strategies

A Shaukat, TR Levin - Nature reviews Gastroenterology & hepatology, 2022 - nature.com
Despite strong evidence of effectiveness, colorectal cancer (CRC) screening remains
underused. Currently, there are several options for CRC screening, each with its own …

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

A Dasari, VK Morris, CJ Allegra, C Atreya… - Nature reviews Clinical …, 2020 - nature.com
An increasing number of studies are describing potential uses of circulating tumour DNA
(ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area …

[HTML][HTML] DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer

D Müller, B Győrffy - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Epigenetic landscape of liquid biopsy in colorectal cancer

A Rodriguez-Casanova, N Costa-Fraga… - Frontiers in Cell and …, 2021 - frontiersin.org
Colorectal cancer (CRC) is one of the most common malignancies and is a major cause of
cancer-related deaths worldwide. Thus, there is a clinical need to improve early detection of …

Epigenetic liquid biopsies for minimal residual disease, what's around the corner?

AD Johnston, JP Ross, C Ma, KYC Fung… - Frontiers in …, 2023 - frontiersin.org
Liquid biopsy assays for minimal residual disease (MRD) are used to monitor and inform
oncological treatment and predict the risk of relapse in cancer patients. To-date, most MRD …

Promising epigenetic biomarkers for the early detection of colorectal cancer: a systematic review

SA Anghel, CB Ioniță-Mîndrican, I Luca, AL Pop - Cancers, 2021 - mdpi.com
Simple Summary High-performance, non-invasive screening is a requirement in colorectal
cancer (CRC) as early detection is a key in reducing disease-related mortality in CRC …

Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1 to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC)

BL Musher, JE Melson, G Amato, D Chan, M Hill… - … Biomarkers & Prevention, 2020 - AACR
Background: Most recurrences of early-stage colorectal cancer detected with current
surveillance measures are widespread and incurable. Circulating tumor DNA (ctDNA) may …

TP53 and/or BRCA1 Mutations Based on CtDNA Analysis as Prognostic Biomarkers for Primary Triple-Negative Breast Cancer

A Arimura, K Sakai, K Kaneshiro, T Morisaki, S Hayashi… - Cancers, 2024 - mdpi.com
Simple Summary For effective cancer treatment, it is important to scrutinize individual driver
gene mutations. In this study, we investigated whether analyzing gene mutations in primary …

[HTML][HTML] Circulating tumor DNA based minimal residual disease detection and adjuvant treatment decision-making for muscle-invasive bladder cancer guided by …

C Nawaf, A Shiang, PS Chauhan, AA Chaudhuri… - Translational …, 2023 - Elsevier
Up to 430,000 cases of bladder cancer are diagnosed each year worldwide. A proposed
method for non-invasive monitoring has been to utilize a “liquid biopsy.” Liquid biopsy has …

Assessment of tumor burden and response to therapy in patients with colorectal cancer using a quantitative ctDNA test for methylated BCAT1/IKZF1

EL Symonds, SK Pedersen, B Yeo, H Al Naji… - Molecular …, 2022 - Wiley Online Library
Failure of colorectal cancer (CRC) treatment is due to residual disease, and its timely
identification is critical for patient survival. Detecting CRC‐associated mutations in patient …