[HTML][HTML] Delivery of biologics: Topical administration

RJ Kulchar, R Singh, S Ding, E Alexander, KW Leong… - Biomaterials, 2023 - Elsevier
Biologics are unaffordable to a large majority of the global population because of
prohibitively expensive fermentation systems, purification and the requirement for cold chain …

Contributions of the international plant science community to the fight against human infectious diseases–part 1: epidemic and pandemic diseases

M Lobato Gomez, X Huang, D Alvarez… - Plant biotechnology …, 2021 - Wiley Online Library
Infectious diseases, also known as transmissible or communicable diseases, are caused by
pathogens or parasites that spread in communities by direct contact with infected individuals …

[HTML][HTML] Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection

H Daniell, SK Nair, N Esmaeili, G Wakade, N Shahid… - Molecular Therapy, 2022 - cell.com
To advance a novel concept of debulking virus in the oral cavity, the primary site of viral
replication, virus-trapping proteins CTB-ACE2 were expressed in chloroplasts and clinical …

Plant cell-based drug delivery enhances affordability of biologics

H Daniell, RJ Kulchar, RW Herzog, M Kulis… - Nature …, 2023 - nature.com
A Correspondence published recently in Nature Biotechnology discussed the
socioeconomic potential and commercial feasibility of plant molecular farming 1. This …

[HTML][HTML] Nanotechnologies for the delivery of biologicals: Historical perspective and current landscape

M Durán-Lobato, AM López-Estévez… - Advanced Drug Delivery …, 2021 - Elsevier
Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene
generating a great hope due to their outstanding specificity and potency. However, given …

Genetically engineered pH-responsive silk sericin nanospheres with efficient therapeutic effect on ulcerative colitis

S Xu, Q Yang, R Wang, C Tian, Y Ji, H Tan, P Zhao… - Acta Biomaterialia, 2022 - Elsevier
Ulcerative colitis (UC) is one type of inflammatory bowel disease (IBD) and lactoferrin (LF) is
a promising protein drug to treat UC. However, targeted LF delivery to optimize …

Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity

B Shanmugaraj, N Khorattanakulchai, C Panapitakkul… - Vaccine, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is an acute respiratory illness caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The prevention of SARS …

Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease …

H Daniell, SK Nair, H Guan, Y Guo, RJ Kulchar… - Biomaterials, 2022 - Elsevier
Because oral transmission of SARS-CoV-2 is 3–5 orders of magnitude higher than nasal
transmission, we investigated debulking of oral viruses using viral trap proteins (CTB-ACE2 …

Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment

H Daniell, SK Nair, Y Shi, P Wang, KT Montone… - … Therapy-Methods & …, 2022 - cell.com
Although several therapeutics are used to treat coronavirus disease 2019 (COVID-19)
patients, there is still no definitive metabolic marker to evaluate disease severity and …

Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and …

W He, C Baysal, M Lobato Gomez… - Plant biotechnology …, 2021 - Wiley Online Library
The fight against infectious diseases often focuses on epidemics and pandemics, which
demand urgent resources and command attention from the health authorities and media …