[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization
TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
TSPO protein binding partners in bacteria, animals, and plants
C Hiser, BL Montgomery, S Ferguson-Miller - Journal of Bioenergetics and …, 2021 - Springer
The ancient membrane protein TSPO is phylogenetically widespread from archaea and
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …
TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma
Background The ligands of mitochondrial translocator protein (TSPO) have been widely
used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in …
used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in …
[HTML][HTML] Infection with bacteroides phage BV01 alters the host transcriptome and bile acid metabolism in a common human gut microbe
Gut-associated phages are hypothesized to alter the abundance and activity of their
bacterial hosts, contributing to human health and disease. Although temperate phages …
bacterial hosts, contributing to human health and disease. Although temperate phages …
Effect of amphiphilic environment on the solution structure of mouse TSPO translocator protein
S Combet, F Bonneté, S Finet, A Pozza, C Saade… - Biochimie, 2023 - Elsevier
The translocator protein (TSPO) is a ubiquitous transmembrane protein of great
pharmacological interest thanks to its high affinity to many drug ligands. The only high …
pharmacological interest thanks to its high affinity to many drug ligands. The only high …
Mitochondrial translocator protein (TSPO) function is not essential for heme biosynthesis
Function of the mammalian translocator protein (TSPO; previously known as the peripheral
benzodiazepine receptor) remains unclear because its presumed role in steroidogenesis …
benzodiazepine receptor) remains unclear because its presumed role in steroidogenesis …
[18F]BIBD-239: 18F-Labeled ER176, a Positron Emission Tomography Tracer Specific for the Translocator Protein
H Chen, Z Jiang, X Cheng, W Zheng, Y Sun… - Molecular …, 2022 - ACS Publications
[11C] ER176 has adequate sensitivity to image the human brain translocator protein (TSPO)
in all three genotypes by positron emission tomography (PET). However, its clinical …
in all three genotypes by positron emission tomography (PET). However, its clinical …
Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: A patent review (2010–2015; part 1)
TH Kim, AN Pae - Expert opinion on therapeutic patents, 2016 - Taylor & Francis
Introduction: The translocator protein (TSPO) is an emerging target in diverse
neurodegenerative diseases. Up-regulated TSPO in the central nervous system (CNS) …
neurodegenerative diseases. Up-regulated TSPO in the central nervous system (CNS) …
Pyrethroid insecticides as the mitochondrial dysfunction inducers
Pyrethroids are used to decrease vector-based health concerns and to increase field yield
against agricultural pests. Their metabolism is a concern to disrupt a cell's homeostatic …
against agricultural pests. Their metabolism is a concern to disrupt a cell's homeostatic …
PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [11C]PBR28
Purpose Brown adipose tissue (BAT) in adult humans has been recently rediscovered and
intensively investigated as a new potential therapeutic target for obesity and type 2 diabetes …
intensively investigated as a new potential therapeutic target for obesity and type 2 diabetes …