This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

In vitro liver cell culture models are gaining increasing importance in pharmacological and
toxicological research. The source of cells used is critical for the relevance and the …

Liver plays a major role in drug metabolism and is one of the main sites of drug adverse
effects. Microphysiological systems (MPS), also known as organs‐on‐a‐chip, are a class of …

Despite the exciting properties and wide-reaching applications of nanobiomaterials (NBMs)
in human health and medicine, their translation from bench to bedside is slow, with a …

Hepatotoxicity is among the most frequent reasons for drug withdrawal from the market.
Therefore, there is an urgent need for reliable predictive in vitro tests, which unfailingly …

A crucial step in lead selection during drug development is accurate estimation and
optimization of hepatic clearance using in vitro methods. However, current methods are …

Biologic substrates, prepared by decellularizing and solubilizing tissues, have been of great
interest in the tissue engineering field because of the preservation of complex biochemical …

Dear editor, It is well known that huge research networks have been initiated by the EU to
establish in vitro test systems for toxicity testing (Liebsch et al., 2011; Bolt, 2013; Krug et al …

This protocol demonstrates a method for obtaining high yield and viability for mouse
hepatocytes and sinusoidal endothelial cells (SECs) suitable for culturing or for obtaining …

Hepatocytes are differentiated cells that account for 80% of the hepatic volume and perform
all major functions of the liver. In vivo, after an acute insult, adult hepatocytes retain their …