Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments
The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …
related disorders remain unclear, but studies in depressed patients and rodent models are …
Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants
The pathophysiology and treatment of depression have been the focus of intense research
and while there is much that remains unknown, modern neurobiological approaches are …
and while there is much that remains unknown, modern neurobiological approaches are …
[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
The physiology of regulated BDNF release
T Brigadski, V Leßmann - Cell and Tissue Research, 2020 - Springer
The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …
Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine
Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine
K Fukumoto, MV Fogaça, RJ Liu… - Proceedings of the …, 2019 - National Acad Sciences
Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces
rapid and long-lasting antidepressant effects in major depressive disorder (MDD) patients.(2 …
rapid and long-lasting antidepressant effects in major depressive disorder (MDD) patients.(2 …
[HTML][HTML] Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide
RS Duman - F1000Research, 2018 - ncbi.nlm.nih.gov
Therapeutic medications for the treatment of depression have serious limitations, particularly
delayed onset and low rates of efficacy. However, the discovery that a single subanesthetic …
delayed onset and low rates of efficacy. However, the discovery that a single subanesthetic …
Glutamatergic neurotransmission: pathway to developing novel rapid-acting antidepressant treatments
The underlying neurobiological basis of major depressive disorder remains elusive due to
the severity, complexity, and heterogeneity of the disorder. While the traditional …
the severity, complexity, and heterogeneity of the disorder. While the traditional …
Convergent mechanisms underlying rapid antidepressant action
Traditional pharmacological treatments for depression have a delayed therapeutic onset,
ranging from several weeks to months, and there is a high percentage of individuals who …
ranging from several weeks to months, and there is a high percentage of individuals who …