Advancements in kidney organoids and tubuloids to study (dys) function
The rising prevalence of kidney diseases urges the need for novel therapies. Kidney
organoids and tubuloids are advanced in vitro models and have recently been described as …
organoids and tubuloids are advanced in vitro models and have recently been described as …
Navigating the kidney organoid: insights into assessment and enhancement of nephron function
N Tabibzadeh, LM Satlin, S Jain… - American Journal of …, 2023 - journals.physiology.org
Kidney organoids are three-dimensional structures generated from pluripotent stem cells
(PSCs) that are capable of recapitulating the major structures of mammalian kidneys. As this …
(PSCs) that are capable of recapitulating the major structures of mammalian kidneys. As this …
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
H Babbe, TB Sundberg, M Tichenor… - Proceedings of the …, 2024 - National Acad Sciences
The salt-inducible kinases (SIK) 1–3 are key regulators of pro-versus anti-inflammatory
cytokine responses during innate immune activation. The lack of highly SIK-family or SIK …
cytokine responses during innate immune activation. The lack of highly SIK-family or SIK …
Stimulation of fracture mineralization by salt-inducible kinase inhibitors
Introduction Over 6.8 million fractures occur annually in the US, with 10% experiencing
delayed-or non-union. Anabolic therapeutics like PTH analogs stimulate fracture repair, and …
delayed-or non-union. Anabolic therapeutics like PTH analogs stimulate fracture repair, and …
Intestinal Cyp24a1 regulates vitamin D locally independent of systemic regulation by renal Cyp24a1 in mice
Vitamin D regulates mineral homeostasis. The most biologically active form of vitamin D, 1,
25-dihydroxyvitamin D (1, 25D), is synthesized by CYP27B1 from 25-dihydroxyvitamin D …
25-dihydroxyvitamin D (1, 25D), is synthesized by CYP27B1 from 25-dihydroxyvitamin D …
Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology
KA Peña, S Savransky, B Lewis - Molecular and Cellular Endocrinology, 2024 - Elsevier
Compartmentalization of GPCR signaling is an emerging topic that highlights the
physiological relevance of spatial bias in signaling. The parathyroid hormone (PTH) type 1 …
physiological relevance of spatial bias in signaling. The parathyroid hormone (PTH) type 1 …
Renal proximal tubule cells: power and finesse
MAA Fuchs, M Wolf - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
The proximal tubule is the high-capacity reabsorptive powerhouse of the kidney. Two papers
in recent issues of the JCI highlight mechanisms of more delicate effects of the proximal …
in recent issues of the JCI highlight mechanisms of more delicate effects of the proximal …
Biology of the proximal tubule in body homeostasis and kidney disease
The proximal tubule (PT) is known as the workhorse of the kidney, for both the range and
magnitude of the functions that it performs. It is not only responsible for reabsorbing most …
magnitude of the functions that it performs. It is not only responsible for reabsorbing most …
Molecular insights into mineralotropic hormone inter-regulation
JW Pike, SM Lee, MB Meyer - Frontiers in Endocrinology, 2023 - frontiersin.org
The regulation of mineral homeostasis involves the three mineralotropic hormones PTH,
FGF23 and 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3). Early research efforts focused on …
FGF23 and 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3). Early research efforts focused on …
Bone and bone derived factors in kidney disease
P Simic - Frontiers in Physiology, 2024 - frontiersin.org
Purpose of review: Mineral and bone disorder (MBD) is a prevalent complication in chronic
kidney disease (CKD), significantly impacting overall health with multifaceted implications …
kidney disease (CKD), significantly impacting overall health with multifaceted implications …